STAGA Complex: Regulation of Gene Expression and Potential Drug Target

Target Name: STAGA complex

NCBI ID: P18439

STAGA complex

Other Name(s): SPT3-TAF9-GCN5 acetyltransferase complex | STAGA coactivator complex

STAGA Complex: Regulation of Gene Expression and Potential Drug Target

The STAGA complex (SPT3-TAF9-GCN5 acetyltransferase complex) is a protein complex that is involved in the acetylation of various transcription factors, including STAGA itself. The STAGA complex is composed of three subunits: SPT3, TAF9, and GCN5. These subunits form a covalent complex that is located in the nucleus of the cell.

The STAGA complex plays a crucial role in the regulation of gene expression and is involved in the development and maintenance of various cellular processes. One of the key functions of the STAGA complex is the acetylation of the transcription factor GCN5, which allows it to bind to DNA and regulate the expression of genes.

The STAGA complex is also involved in the regulation of cellular processes such as cell division, apoptosis, and DNA damage repair. It plays a key role in the regulation of the SAS-GATA transcription factor, which is involved in the regulation of gene expression and is a target for many diseases, including cancer.

The STAGA complex is composed of three subunits: SPT3, TAF9, and GCN5. SPT3 and TAF9 are both nuclear proteins that are involved in the regulation of gene expression. GCN5 is a smaller protein that is also located in the nucleus.

SPT3 is a key subunit of the STAGA complex that is involved in the acetylation of GCN5. It has a molecular weight of approximately 46 kDa and is composed of a unique nucleotide-binding domain and a catalytic domain. The nucleotide-binding domain is responsible for binding to DNA and the catalytic domain is responsible for the acetylation of GCN5.

TAF9 is another key subunit of the STAGA complex that is involved in the regulation of gene expression. It has a molecular weight of approximately 34 kDa and is composed of a nucleotide-binding domain and a catalytic domain. The nucleotide-binding domain is responsible for binding to DNA and the catalytic domain is responsible for the regulation of gene expression.

GCN5 is the smallest subunit of the STAGA complex and is responsible for the regulation of gene expression. It has a molecular weight of approximately 28 kDa and is composed of a unique nucleotide-binding domain and a catalytic domain. The nucleotide-binding domain is responsible for binding to DNA and the catalytic domain is responsible for the regulation of gene expression.

The STAGA complex plays a crucial role in the regulation of gene expression and is involved in the development and maintenance of various cellular processes. It is a potential drug target and may be a biomarker for the treatment of various diseases.

Protein Name: STAGA Complex

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